As I understood after discussing this in several Flexhubs

it is highly unlikely that the hub will receive the original sender's MAC address, since it can change on every hop. It's mostly used for traffic between two endpoints without any intermediates: a LAN for example.
Even then a MAC address is still easy to spoof, way easier than spoofing an IP for example.
So MAC filtering/binding won't be included as an option in FlexHub.
A related feature already exist in ADC:
FlexHub will have the option (after beta) to bind an account to a certain CID. A CID is generated by the client based on the PID (a unique Personal IDentifier). The PID/CID combination is only known to the hub, and the hub checks if the CID is a proper hash of the user's PID. The PID is never shown to any other clients, only the CID is used for client-client-communication.
Security of this is just as weak as a MAC address would be though, a malicious hub can easily harvest PID/CID combinations. It would only require tricking someone in connecting to that malicious hub.